Shenbagamoorthy Sundarraj

V.O.Chidambaram College, Tuticorin · Department of Zoology

The nanoparticles or nanobots are equivalent to the size of biological molecules of the human body and this is claimed to be the massive advantage of nanotechnology. Currently, top-down and bottom-up fabrication methods are being adopted to synthesize nanomaterials. Hence, the products developed from nanotechnology can be used for assessment of sev...

Aims: Hexavalent chromium Cr(VI), a toxic heavy metal, is a serious pollutant of tannery effluent, and its accumulation in soil and water causes severe environmental concerns of increasing public health issues. The present study focus on the isolation and identification of chromium-reducing bacteria collected from the tannery industry in Dindigul,...

Emerging proteomic technologies offer new insight in the study of malignant tumor to identify protein biomarkers for early detection, stratification, prediction and monitoring of treatment, as well as to detect target molecules for therapy. The tumor protein biomarker is responsible for the regulation of the cell cycle to promote cell proliferation...

Carbon quantum dots (CQDs) have gained significant growing attention in the recent past due to their peculiar characteristics including smaller size, high surface area, photoluminescence, chemical stability, facile synthesis and functionalization possibilities. They are carbon nanostructures having less than 10 nm size with fluorescent properties....

Nanotechnology is a pioneering field among the diverse fields of science, including insect pest management. Mosquito-borne diseases have an important public health issues in morbidity and mortality worldwide. They include malaria, yellow fever, Japanese encephalitis, filariasis and dengue fever. The development of insecticide-resistant mosquito spe...

SiO 2 @TiO 2 thin films synthesis and their UV protective application in the microorganism and molecular response for the embryonic development of Zebrafish was elucidated. The SiO 2 @TiO 2 thin films were fabricated on...

Experimental evidence from the etiology of cancer studies suggests that a correlation between Bisphenol-A (BPA) exposure and alterations in hematopoiesis leads to blood cancer. In our study zebrafish were used to assess the lethality, developmental effect, embryonic apoptosis and changes in transcription factor of hematopoiesis through EGFR/ERK sig...

Controlling biofilms of bacteria is a challenging aspect because of their drug-resistance potentials against a range of antibiotics, demanding the development of active anti-biofilm agents. Rutin (R), a natural antioxidant, and benzamide (B), a synthetic antibacterial agent, have several pharmacological and antibacterial abilities. Herein, we devel...

The biofunctional significance of hollow mesoporous silica nanoparticles (HMSNs) could be used as nano-reservoirs. Here in the β-sitosterol loaded into the hollow core and the cisplatin substituted with the carboxylic group of poly lactic acid (PLA)- polyethylene glycol (PEG) on the pore walls of HMSNs. Subsequently, the tumour biomarker somatostat...

Modern therapies for malignant breast cancer in clinics are not efficacious and often result in deprived patient compliance owing to squat therapeutic effectiveness and strong systemic side effects. In order to overcome this, we combined chemo-photothermal targeted therapy of breast cancer within one novel multifunctional drug delivery system. Foli...

Cancer nanotheranostic materials are useful in real-time monitoring of drug delivery and therapeutic action against tumor cells as they co-deliver therapeutic and imaging functions. In this study, we report the use of natural fluorescent protein (R-Phycoerythrin (PE)) in the preparation of novel multifunctional Chitosan-Silver-Phycoerythrin Nanocom...

Epidermal growth factor receptor antibody (EGFRAb) conjugated silica nanorattles (SN) were synthesized and used to develop receptor mediated endocytosis for targeted drug delivery strategies for cancer therapy. The present study determined that, the rate of internalization of silica nanorattles was found to be high in lung cancer cells when compare...

The E2F3 transcription factor claims its role in controlling cell cycle progression. As reported earlier, nuclear E2F3 overexpression leads to development of bladder and prostate cancer in humans. Accordingly, the present investigation has been designed to assess to what extent E2F3 would be overexpressed in breast cancer. The aim of this study was...

ARCMED-D-11-00656). Background and Aims. The E2F3 transcription factor claims its role in controlling cell cycle progression. As reported earlier, nuclear E2F3 overexpression leads to development of bladder and prostate cancer in humans. Accordingly, the present investigation has been designed to assess to what extent E2F3 would be overexpressed in...

Acacia nilotica is widely distributed in Asia. In India, it occupies an important place in the indigenous system of medicine against anti-inflammatory, antioxidant, cancers, and/or tumors. The purpose of this study is to investigate the inhibitory effect of Acacia nilotica leaves extract and γ-Sitosterol on cell proliferation, the apoptotic effect...

The aim of this study was to investigate the expression of cPLA(2)α in non-small lung cancer cell lines and tissues, and we sought to determine the in vitro effects of the pyrrolidine-2 inhibitor on cPLA(2)α sensitivity in three different non-small lung cancer cell lines. The expression of cPLA(2)α was determined in lung cancer cells by Western blo...

Purpose The aim of this study was to investigate the expression of cPLA 2 a in non-small lung cancer cell lines and tissues, and we sought to determine the in vitro effects of the pyrrolidine-2 inhibitor on cPLA 2 a sensitivity in three different non-small lung cancer cell lines. Methods The expression of cPLA 2 a was determined in lung cancer cell...

Cleome viscosa is an important medicinal herb. Mass collection of the plant from natural habitats has led to its depletion. We have established a protocol for its mass propagation through in vitro organogenesis using leaf explants. For callus induction it was found that Indole-3acetic acid (2mg/l) has a significant effect on the callus induction, c...

Purpose: Cytosolic phospholipase A(2)alpha is the main target enzyme for the non steroidal anti-inflammatory drugs that have been shown to suppress carcinogenesis in both experimental model and epidemiologic studies. Methods: We examined cPLA(2)alpha expression in normal, premalignant bronchial epithelial cells and nonsmall cell lung carcinoma (NSC...

Cytosolic phospholipase A2α is the main target enzyme for the non steroidal anti-inflammatory drugs that have been shown to suppress carcinogenesis in both experimental model and epidemiologic studies. We examined cPLA2α expression in normal, premalignant bronchial epithelial cells and nonsmall cell lung carcinoma (NSCLC) samples using an immunohis...

Problem statement: It is widely accepted thought that the weak promoters control the RNA synthesis and play regulatory role in complex genetic networks in bacterial system. An experiment had been designed to address whether mutations in the -16/-17 region affect the rate of transcription at an activator-independent promoter in E. coli or not? Appro...